Cystic fibrosis: The ciliary inhibitor is a small polypeptide associated with immunoglobulin G

B. H. Bowman; B. J. Lankford; G. M. Fuller; S. D. Carson; A. Kurosky; D. R. Barnett

doi:10.1016/0006-291X(75)90835-9

Cystic fibrosis: The ciliary inhibitor is a small polypeptide associated with immunoglobulin G

B. H. Bowman, B. J. Lankford, G. M. Fuller, S. D. Carson, A. Kurosky, D. R. Barnett

Research output: Contribution to journal › Article › peer-review

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Abstract

A small polypeptide within the molecular weight range of 6,000 to 11,000 was found in immunoglobulin fractions from sera of cystic fibrosis homozygotes and heterozygotes. This factor appears to be responsible for interfering with ciliary activity in oyster gills. Since it can be dissociated from IgG without reductive cleavage it must be bound in a non-covalent manner. After its dissociation the IgG fractions from cystic fibrosis sera no longer inhibited ciliary activity. This finding explains the differences previously observed in the molecular weights of the ciliary inhibitor synthesized by cultured cells and that of sera from cystic fibrosis genotypes.

Original language	English (US)
Pages (from-to)	1310-1315
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	64
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(75)90835-9
State	Published - Jun 16 1975
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "A small polypeptide within the molecular weight range of 6,000 to 11,000 was found in immunoglobulin fractions from sera of cystic fibrosis homozygotes and heterozygotes. This factor appears to be responsible for interfering with ciliary activity in oyster gills. Since it can be dissociated from IgG without reductive cleavage it must be bound in a non-covalent manner. After its dissociation the IgG fractions from cystic fibrosis sera no longer inhibited ciliary activity. This finding explains the differences previously observed in the molecular weights of the ciliary inhibitor synthesized by cultured cells and that of sera from cystic fibrosis genotypes.",

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T2 - The ciliary inhibitor is a small polypeptide associated with immunoglobulin G

AU - Bowman, B. H.

AU - Lankford, B. J.

AU - Fuller, G. M.

AU - Carson, S. D.

AU - Kurosky, A.

AU - Barnett, D. R.

PY - 1975/6/16

Y1 - 1975/6/16

N2 - A small polypeptide within the molecular weight range of 6,000 to 11,000 was found in immunoglobulin fractions from sera of cystic fibrosis homozygotes and heterozygotes. This factor appears to be responsible for interfering with ciliary activity in oyster gills. Since it can be dissociated from IgG without reductive cleavage it must be bound in a non-covalent manner. After its dissociation the IgG fractions from cystic fibrosis sera no longer inhibited ciliary activity. This finding explains the differences previously observed in the molecular weights of the ciliary inhibitor synthesized by cultured cells and that of sera from cystic fibrosis genotypes.

AB - A small polypeptide within the molecular weight range of 6,000 to 11,000 was found in immunoglobulin fractions from sera of cystic fibrosis homozygotes and heterozygotes. This factor appears to be responsible for interfering with ciliary activity in oyster gills. Since it can be dissociated from IgG without reductive cleavage it must be bound in a non-covalent manner. After its dissociation the IgG fractions from cystic fibrosis sera no longer inhibited ciliary activity. This finding explains the differences previously observed in the molecular weights of the ciliary inhibitor synthesized by cultured cells and that of sera from cystic fibrosis genotypes.

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Cystic fibrosis: The ciliary inhibitor is a small polypeptide associated with immunoglobulin G

Abstract

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