Cystic fibrosis: Characterization of the inhibitor to ciliary action in oyster gills

Barbara H. Bowman; Michael L. McCombs; Lillian H. Lockhart

doi:10.1126/science.167.3919.871

Cystic fibrosis: Characterization of the inhibitor to ciliary action in oyster gills

Barbara H. Bowman, Michael L. McCombs, Lillian H. Lockhart

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Abstract

The inhibitor to oyster ciliary activity was isolated from serum of cystic fibrosis patients and heterozygotes. The inhibiting protein fraction was a cation as judged by electrophoresis; it had a molecular weight of 125,000 to 200,000 as judged by gel filtration; and on diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster ciliary activity.

Original language	English (US)
Pages (from-to)	871-873
Number of pages	3
Journal	Science
Volume	167
Issue number	3919
DOIs	https://doi.org/10.1126/science.167.3919.871
State	Published - 1970
Externally published	Yes

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title = "Cystic fibrosis: Characterization of the inhibitor to ciliary action in oyster gills",

abstract = "The inhibitor to oyster ciliary activity was isolated from serum of cystic fibrosis patients and heterozygotes. The inhibiting protein fraction was a cation as judged by electrophoresis; it had a molecular weight of 125,000 to 200,000 as judged by gel filtration; and on diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster ciliary activity.",

author = "Bowman, {Barbara H.} and McCombs, {Michael L.} and Lockhart, {Lillian H.}",

year = "1970",

doi = "10.1126/science.167.3919.871",

language = "English (US)",

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TY - JOUR

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T2 - Characterization of the inhibitor to ciliary action in oyster gills

AU - Bowman, Barbara H.

AU - McCombs, Michael L.

AU - Lockhart, Lillian H.

PY - 1970

Y1 - 1970

N2 - The inhibitor to oyster ciliary activity was isolated from serum of cystic fibrosis patients and heterozygotes. The inhibiting protein fraction was a cation as judged by electrophoresis; it had a molecular weight of 125,000 to 200,000 as judged by gel filtration; and on diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster ciliary activity.

AB - The inhibitor to oyster ciliary activity was isolated from serum of cystic fibrosis patients and heterozygotes. The inhibiting protein fraction was a cation as judged by electrophoresis; it had a molecular weight of 125,000 to 200,000 as judged by gel filtration; and on diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster ciliary activity.

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ER -

Cystic fibrosis: Characterization of the inhibitor to ciliary action in oyster gills

Abstract

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