Cysteine sulfinic acid decarboxylase in rat brain: Effect of vitamin B6 deficiency on soluble and particulate components

David K. Rassin; John A. Sturman

doi:10.1016/0024-3205(75)90003-X

Cysteine sulfinic acid decarboxylase in rat brain: Effect of vitamin B₆ deficiency on soluble and particulate components

David K. Rassin, John A. Sturman

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Abstract

Cysteine sulfinic acid decarboxylase activity is not affected when measured in vitro in the presence of pyridoxal phosphate in the brains of vitamin B₆-deficient rats. Activity of this enzyme was not detectable in the brains of vitamin B₆-deficient animals when assayed in the absence of pyridoxal phosphate. The activity of cysteine sulfinic acid decarboxylase in crude particulate and soluble fractions of rat brain reflects the distribution of the enzyme in vivo and the distribution of endogenous B₆ vitamers when assayed in the presence and absence of vitamin B₆. This study indicates that virtually no taurine is synthesized by any component of brain when the animal is subjected to a deficiency of vitamin B₆.

Original language	English (US)
Pages (from-to)	875-881
Number of pages	7
Journal	Life Sciences
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(75)90003-X
State	Published - Mar 15 1975
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(75)90003-X

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abstract = "Cysteine sulfinic acid decarboxylase activity is not affected when measured in vitro in the presence of pyridoxal phosphate in the brains of vitamin B6-deficient rats. Activity of this enzyme was not detectable in the brains of vitamin B6-deficient animals when assayed in the absence of pyridoxal phosphate. The activity of cysteine sulfinic acid decarboxylase in crude particulate and soluble fractions of rat brain reflects the distribution of the enzyme in vivo and the distribution of endogenous B6 vitamers when assayed in the presence and absence of vitamin B6. This study indicates that virtually no taurine is synthesized by any component of brain when the animal is subjected to a deficiency of vitamin B6.",

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N2 - Cysteine sulfinic acid decarboxylase activity is not affected when measured in vitro in the presence of pyridoxal phosphate in the brains of vitamin B6-deficient rats. Activity of this enzyme was not detectable in the brains of vitamin B6-deficient animals when assayed in the absence of pyridoxal phosphate. The activity of cysteine sulfinic acid decarboxylase in crude particulate and soluble fractions of rat brain reflects the distribution of the enzyme in vivo and the distribution of endogenous B6 vitamers when assayed in the presence and absence of vitamin B6. This study indicates that virtually no taurine is synthesized by any component of brain when the animal is subjected to a deficiency of vitamin B6.

AB - Cysteine sulfinic acid decarboxylase activity is not affected when measured in vitro in the presence of pyridoxal phosphate in the brains of vitamin B6-deficient rats. Activity of this enzyme was not detectable in the brains of vitamin B6-deficient animals when assayed in the absence of pyridoxal phosphate. The activity of cysteine sulfinic acid decarboxylase in crude particulate and soluble fractions of rat brain reflects the distribution of the enzyme in vivo and the distribution of endogenous B6 vitamers when assayed in the presence and absence of vitamin B6. This study indicates that virtually no taurine is synthesized by any component of brain when the animal is subjected to a deficiency of vitamin B6.

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Cysteine sulfinic acid decarboxylase in rat brain: Effect of vitamin B₆ deficiency on soluble and particulate components

Abstract

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