Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014

Alireza A. Shamshirsaz; Zhoobin H. Bateni; Haleh Sangi-Haghpeykar; Sara E. Arian; Hadi Erfani; Amir A. Shamshirsaz; Alfred Abuhamad; Karin A. Fox; Susan M. Ramin; Amirhossein Moaddab; Shiraz A. Maskatia; Bahram Salmanian; Keila N. Lopez; Pardis Hosseinzadeh; Amy K. Schutt; Ahmed A. Nassr; Jimmy Espinoza; Gary A. Dildy; Michael A. Belfort; Steven L. Clark

doi:10.1136/heartjnl-2017-312015

Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014

Alireza A. Shamshirsaz, Zhoobin H. Bateni, Haleh Sangi-Haghpeykar, Sara E. Arian, Hadi Erfani, Amir A. Shamshirsaz, Alfred Abuhamad, Karin A. Fox, Susan M. Ramin, Amirhossein Moaddab, Shiraz A. Maskatia, Bahram Salmanian, Keila N. Lopez, Pardis Hosseinzadeh, Amy K. Schutt, Ahmed A. Nassr, Jimmy Espinoza, Gary A. Dildy, Michael A. Belfort, Steven L. Clark

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. Methods: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC). Results: Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks. Conclusions: Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment.

Original language	English (US)
Pages (from-to)	945-948
Number of pages	4
Journal	Heart
Volume	104
Issue number	11
DOIs	https://doi.org/10.1136/heartjnl-2017-312015
State	Published - Jun 1 2018
Externally published	Yes

Keywords

congenital heart disease
echocardiography
epidemiology

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1136/heartjnl-2017-312015

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Shamshirsaz, A. A., Bateni, Z. H., Sangi-Haghpeykar, H., Arian, S. E., Erfani, H., Shamshirsaz, A. A., Abuhamad, A., Fox, K. A., Ramin, S. M., Moaddab, A., Maskatia, S. A., Salmanian, B., Lopez, K. N., Hosseinzadeh, P., Schutt, A. K., Nassr, A. A., Espinoza, J., Dildy, G. A., Belfort, M. A., & Clark, S. L. (2018). Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014. Heart, 104(11), 945-948. https://doi.org/10.1136/heartjnl-2017-312015

Shamshirsaz, AA, Bateni, ZH, Sangi-Haghpeykar, H, Arian, SE, Erfani, H, Shamshirsaz, AA, Abuhamad, A, Fox, KA, Ramin, SM, Moaddab, A, Maskatia, SA, Salmanian, B, Lopez, KN, Hosseinzadeh, P, Schutt, AK, Nassr, AA, Espinoza, J, Dildy, GA, Belfort, MA & Clark, SL 2018, 'Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014', Heart, vol. 104, no. 11, pp. 945-948. https://doi.org/10.1136/heartjnl-2017-312015

@article{e879921758ab440e994c784a1a609ae9,

title = "Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014",

abstract = "Objective: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. Methods: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC). Results: Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks. Conclusions: Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment.",

keywords = "congenital heart disease, echocardiography, epidemiology",

author = "Shamshirsaz, {Alireza A.} and Bateni, {Zhoobin H.} and Haleh Sangi-Haghpeykar and Arian, {Sara E.} and Hadi Erfani and Shamshirsaz, {Amir A.} and Alfred Abuhamad and Fox, {Karin A.} and Ramin, {Susan M.} and Amirhossein Moaddab and Maskatia, {Shiraz A.} and Bahram Salmanian and Lopez, {Keila N.} and Pardis Hosseinzadeh and Schutt, {Amy K.} and Nassr, {Ahmed A.} and Jimmy Espinoza and Dildy, {Gary A.} and Belfort, {Michael A.} and Clark, {Steven L.}",

year = "2018",

month = jun,

day = "1",

doi = "10.1136/heartjnl-2017-312015",

language = "English (US)",

volume = "104",

pages = "945--948",

journal = "Heart",

issn = "1355-6037",

publisher = "BMJ Publishing Group",

number = "11",

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TY - JOUR

T1 - Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014

AU - Shamshirsaz, Alireza A.

AU - Bateni, Zhoobin H.

AU - Sangi-Haghpeykar, Haleh

AU - Arian, Sara E.

AU - Erfani, Hadi

AU - Shamshirsaz, Amir A.

AU - Abuhamad, Alfred

AU - Fox, Karin A.

AU - Ramin, Susan M.

AU - Moaddab, Amirhossein

AU - Maskatia, Shiraz A.

AU - Salmanian, Bahram

AU - Lopez, Keila N.

AU - Hosseinzadeh, Pardis

AU - Schutt, Amy K.

AU - Nassr, Ahmed A.

AU - Espinoza, Jimmy

AU - Dildy, Gary A.

AU - Belfort, Michael A.

AU - Clark, Steven L.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objective: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. Methods: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC). Results: Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks. Conclusions: Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment.

AB - Objective: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. Methods: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC). Results: Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks. Conclusions: Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment.

KW - congenital heart disease

KW - echocardiography

KW - epidemiology

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JO - Heart

JF - Heart

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ER -

Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014

Abstract

Keywords

ASJC Scopus subject areas

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