CXCR2 chemokine receptor – a master regulator in cancer and physiology

Gwendal Lazennec; Krishna Rajarathnam; Ann Richmond

doi:10.1016/j.molmed.2023.09.003

CXCR2 chemokine receptor – a master regulator in cancer and physiology

Gwendal Lazennec, Krishna Rajarathnam, Ann Richmond

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. The recent unfolding of the role of CXCR2 in numerous cancers has led to extensive evaluation of multiple CXCR2 antagonists in preclinical and clinical studies. In this review we discuss the potential of targeting CXCR2 for cancer treatment.

Original language	English (US)
Pages (from-to)	37-55
Number of pages	19
Journal	Trends in Molecular Medicine
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.molmed.2023.09.003
State	Published - Jan 2024
Externally published	Yes

Keywords

CXCR2
cancer
chemokine receptor
glycosaminoglycan
inflammation
neutrophil

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2023.09.003

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title = "CXCR2 chemokine receptor – a master regulator in cancer and physiology",

abstract = "Recent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. The recent unfolding of the role of CXCR2 in numerous cancers has led to extensive evaluation of multiple CXCR2 antagonists in preclinical and clinical studies. In this review we discuss the potential of targeting CXCR2 for cancer treatment.",

keywords = "CXCR2, cancer, chemokine receptor, glycosaminoglycan, inflammation, neutrophil",

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AU - Rajarathnam, Krishna

AU - Richmond, Ann

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AB - Recent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. The recent unfolding of the role of CXCR2 in numerous cancers has led to extensive evaluation of multiple CXCR2 antagonists in preclinical and clinical studies. In this review we discuss the potential of targeting CXCR2 for cancer treatment.

KW - CXCR2

KW - cancer

KW - chemokine receptor

KW - glycosaminoglycan

KW - inflammation

KW - neutrophil

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CXCR2 chemokine receptor – a master regulator in cancer and physiology

Abstract

Keywords

ASJC Scopus subject areas

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