Ct appearance of primary cns lymphoma in patients with acquired immunodeficiency syndrome

Jeffrey D. Goldstein, Barbara Zeifer, Celia Chao, Franklin G. Moser, Dennis W. Dickson, Alan D. Hirschfeld, Lawrence Davis

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Cranial CT studies of 32 patients with biopsy-proven AIDS-related primary CNS lymphoma were reviewed retrospectively. A wide variety of different CT appearances were identified. Mass lesions varied in location, size, and number. Most lesions were either iso- or hyperdense and all enhanced with contrast medium. Several different patterns of enhancement were observed. Mass effect and edema were seen in almost all patients. After radiotherapy, most tumors decreased in diameter, became hypodense, and no longer enhanced with contrast medium. Edema and mass effect decreased or resolved in all but one patient. Postradiotherapy CT scans also revealed interval enlargement of the ventricles and cortical sulci. This study demonstrates the wide diversity of CT appearances of AIDS-related primary CNS lymphoma. The CT findings cannot be used in lieu of biopsy for diagnosis of this disorder. The appearance of postradiotherapy CT scans was consistent with regressing lymphoma.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalJournal of Computer Assisted Tomography
Issue number1
StatePublished - 1991
Externally publishedYes


  • Acquired immunodeficiency syndrome
  • Brain neoplasms
  • Central nervous system neoplasms
  • Computed tomography
  • Lymphoma
  • Radiation therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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