Cryoprecipitate utilization patterns observed with a required prospective approval process vs electronic dosing guidance

Robert L. Kruse, Melissa Neally, Brian C. Cho, Evan M. Bloch, Parvez M. Lokhandwala, Paul M. Ness, Steven M. Frank, Aaron A.R. Tobian, Eric A. Gehrie

Research output: Contribution to journalArticlepeer-review


Objectives: We evaluated the impact of electronic medical record (EMR)-guided pooled cryoprecipitate dosing vs our previous practice of requiring transfusion medicine (TM) resident approval for every cryoprecipitate transfusion. Methods: At our hospital, cryoprecipitate pooled from five donors is dosed for adult patients, while single-donor cryoprecipitate is dosed for pediatric patients (defined as patients <50 kg in weight). EMR-based dosing guidance replaced a previously required TM consultation when cryoprecipitate pools were ordered, but a consultation remained required for single-unit orders. Usage was defined as thawed cryoprecipitate; wastage was defined as cryoprecipitate that expired prior to transfusion. Results: In the 6 months prior to intervention, 178 ± 13 doses of pooled cryoprecipitate were used per month vs 187 ± 15 doses after the intervention (P = .68). Wastage of pooled cryoprecipitate increased from 7.7% ± 1.5% to 12.7% ± 1.4% (P = .038). There was no change in wastage of pediatric cryoprecipitate doses during the study period. These trends remained unchanged for a full year postimplementation. Conclusions: Electronic dosing guidance resulted in similar cryoprecipitate usage as TM auditing. Increased wastage may result from reduced TM oversight. Product wastage should be balanced against the possibility that real-time audits could delay a lifesaving therapy.

Original languageEnglish (US)
Pages (from-to)362-368
Number of pages7
JournalAmerican journal of clinical pathology
Issue number3
StatePublished - 2020
Externally publishedYes


  • Cryoprecipitate
  • Electronic medical records
  • Patient blood management

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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