Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Huiling Cao; Ke Zhu; Lugui Qiu; Shuai Li; Hanjie Niu; Mu Hao; Shengyong Yang; Zhongfang Zhao; Yumei Lai; Judith L. Anderson; Jie Fan; Hee Jeong Im; Di Chen; G. David Roodman; Guozhi Xiao

doi:10.1074/jbc.M113.469973

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Huiling Cao, Ke Zhu, Lugui Qiu, Shuai Li, Hanjie Niu, Mu Hao, Shengyong Yang, Zhongfang Zhao, Yumei Lai, Judith L. Anderson, Jie Fan, Hee Jeong Im, Di Chen, G. David Roodman, Guozhi Xiao

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

Original language	English (US)
Pages (from-to)	30399-30410
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.469973
State	Published - Oct 18 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.469973

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title = "Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis",

abstract = "Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.",

author = "Huiling Cao and Ke Zhu and Lugui Qiu and Shuai Li and Hanjie Niu and Mu Hao and Shengyong Yang and Zhongfang Zhao and Yumei Lai and Anderson, {Judith L.} and Jie Fan and Im, {Hee Jeong} and Di Chen and Roodman, {G. David} and Guozhi Xiao",

year = "2013",

month = oct,

day = "18",

doi = "10.1074/jbc.M113.469973",

language = "English (US)",

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TY - JOUR

T1 - Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

AU - Cao, Huiling

AU - Zhu, Ke

AU - Qiu, Lugui

AU - Li, Shuai

AU - Niu, Hanjie

AU - Hao, Mu

AU - Yang, Shengyong

AU - Zhao, Zhongfang

AU - Lai, Yumei

AU - Anderson, Judith L.

AU - Fan, Jie

AU - Im, Hee Jeong

AU - Chen, Di

AU - Roodman, G. David

AU - Xiao, Guozhi

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

AB - Background: Myeloma cells cause abnormal osteoclast formation and osteolysis. Results: Myeloma cells up-regulate AKT in osteoclast precursors and promote osteoclast formation. Systemic AKT inhibition blocks the myeloma-induced osteolysis and tumor growth in bone. Conclusion: AKT is critical for the myeloma promotion of osteoclast formation and osteolysis. Significance: AKT could be a useful target for treating patients with myeloma bone disease.

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DO - 10.1074/jbc.M113.469973

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SN - 0021-9258

VL - 288

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EP - 30410

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Abstract

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