Crimean-Congo hemorrhagic fever virus genomics and global diversity

Varough M. Deyde, Marina L. Khristova, Pierre E. Rollin, Thomas G. Ksiazek, Stuart T. Nichol

Research output: Contribution to journalArticlepeer-review

178 Scopus citations


Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high case fatality that occurs in Africa, Europe, the Middle East, and Asia. The complete genomes of 13 geographically and temporally diverse virus strains were determined, and CCHF viruses were found to be highly variable with 20 and 8%, 31 and 27%, and 22 and 10% nucleotide and deduced amino acid differences detected among virus S (nucleocapsid), M (glycoprotein), and L (polymerase) genome segments, respectively. Distinct geographic lineages exist, but with multiple exceptions indicative of long-distance virus movement. Discrepancies among the virus S, M, and L phylogenetic tree topologies document multiple RNA segment reassortment events. An analysis of individual segment datasets suggests genetic recombination also occurs. For an arthropod-borne virus, the genomic plasticity of CCHF virus is surprisingly high.

Original languageEnglish (US)
Pages (from-to)8834-8842
Number of pages9
JournalJournal of virology
Issue number17
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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