CREB modulates excitability of nucleus accumbens neurons

Yan Dong; Thomas Green; Daniel Saal; Helene Marie; Rachael Neve; Eric J. Nestler; Robert C. Malenka

doi:10.1038/nn1661

CREB modulates excitability of nucleus accumbens neurons

Yan Dong, Thomas Green, Daniel Saal, Helene Marie, Rachael Neve, Eric J. Nestler, Robert C. Malenka

Research output: Contribution to journal › Article › peer-review

242 Scopus citations

Abstract

Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

Original language	English (US)
Pages (from-to)	475-477
Number of pages	3
Journal	Nature Neuroscience
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/nn1661
State	Published - Apr 2006
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "CREB modulates excitability of nucleus accumbens neurons",

abstract = "Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.",

author = "Yan Dong and Thomas Green and Daniel Saal and Helene Marie and Rachael Neve and Nestler, {Eric J.} and Malenka, {Robert C.}",

note = "Funding Information: We thank E. Sura and W. Ju for technical assistance and J. Trimmer, R.C. Yu and R. Axel for providing constructs. This work was supported by grants from the National Institute on Drug Abuse and the US National Institute of Mental Health.",

year = "2006",

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doi = "10.1038/nn1661",

language = "English (US)",

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pages = "475--477",

journal = "Nature Neuroscience",

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T1 - CREB modulates excitability of nucleus accumbens neurons

AU - Dong, Yan

AU - Green, Thomas

AU - Saal, Daniel

AU - Marie, Helene

AU - Neve, Rachael

AU - Nestler, Eric J.

AU - Malenka, Robert C.

N1 - Funding Information: We thank E. Sura and W. Ju for technical assistance and J. Trimmer, R.C. Yu and R. Axel for providing constructs. This work was supported by grants from the National Institute on Drug Abuse and the US National Institute of Mental Health.

PY - 2006/4

Y1 - 2006/4

N2 - Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

AB - Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

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CREB modulates excitability of nucleus accumbens neurons

Abstract

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