Cortisol stimulation by recombinant interferon-α2

Joe Roosth; Richard B. Pollard; S. Lori Brown; Walter J. Meyer

doi:10.1016/0165-5728(86)90037-8

Cortisol stimulation by recombinant interferon-α₂

Joe Roosth, Richard B. Pollard, S. Lori Brown, Walter J. Meyer

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α₂. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α₂. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 10⁶ units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

Original language	English (US)
Pages (from-to)	311-316
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0165-5728(86)90037-8
State	Published - Oct 1986

Keywords

Cortisol stimulation
Interferon-α
Serum
Tumor
recombinant

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/0165-5728(86)90037-8

Cite this

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title = "Cortisol stimulation by recombinant interferon-α2",

abstract = "Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.",

keywords = "Cortisol stimulation, Interferon-α, Serum, Tumor, recombinant",

author = "Joe Roosth and Pollard, {Richard B.} and Brown, {S. Lori} and Meyer, {Walter J.}",

note = "Funding Information: This work was supported in part by the NIH Research Grant NS 07189 and HL 20201. The work was also supported by Grant RR73 from the Clinical Research Center Program of the Division of Research Resource, National Institute of Public Health Service. We thank Ms. Gloria Collins for typing the manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1986",

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T1 - Cortisol stimulation by recombinant interferon-α2

AU - Roosth, Joe

AU - Pollard, Richard B.

AU - Brown, S. Lori

AU - Meyer, Walter J.

N1 - Funding Information: This work was supported in part by the NIH Research Grant NS 07189 and HL 20201. The work was also supported by Grant RR73 from the Clinical Research Center Program of the Division of Research Resource, National Institute of Public Health Service. We thank Ms. Gloria Collins for typing the manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1986/10

Y1 - 1986/10

N2 - Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

AB - Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

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