TY - JOUR
T1 - Correlation of nonspecific antiviral activity with the ability to isolate infectious HIV-1 from Saliva
AU - Coppenhaver, Dorian H.
AU - Sriyuktasuth-Woo, Pat
AU - Baron, Samuel
AU - Barr, Charles E.
AU - Qureshi, M. Nasar
PY - 1994/5/5
Y1 - 1994/5/5
N2 - To the Editor: Despite evidence of HIV in the saliva of HIV-positive persons, oral transmission of the virus appears to be a rare event. Researchers have isolated infectious virus from only a small percentage of saliva samples from HIV-infected patients, even when virus can be isolated from peripheral-blood samples from the same persons1,2 or when HIV DNA is detected in saliva by the polymerase chain reaction3. Components of saliva can inhibit HIV4 and other viruses5. Can the presence of salivary viral inhibitors explain the low rate of recovery of HIV from oral fluids? Recently, we tested saliva.
AB - To the Editor: Despite evidence of HIV in the saliva of HIV-positive persons, oral transmission of the virus appears to be a rare event. Researchers have isolated infectious virus from only a small percentage of saliva samples from HIV-infected patients, even when virus can be isolated from peripheral-blood samples from the same persons1,2 or when HIV DNA is detected in saliva by the polymerase chain reaction3. Components of saliva can inhibit HIV4 and other viruses5. Can the presence of salivary viral inhibitors explain the low rate of recovery of HIV from oral fluids? Recently, we tested saliva.
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U2 - 10.1056/NEJM199405053301815
DO - 10.1056/NEJM199405053301815
M3 - Letter
C2 - 8145793
AN - SCOPUS:0028300429
SN - 0028-4793
VL - 330
SP - 1314
EP - 1315
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -