TY - JOUR
T1 - Correlation between insulin resistance and severity of coronary artery disease in non-diabetes
AU - Shenoy, Rohit
AU - Bhat, Rajesh
AU - Srinivasan, Mukund
AU - Mahabala, Chakrapani
AU - Bhaskaran, Unnikrishnan
N1 - Publisher Copyright:
© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
PY - 2016/11
Y1 - 2016/11
N2 - Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in non-diabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in non-diabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.
AB - Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in non-diabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in non-diabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.
KW - Coronary artery disease
KW - Gensini score
KW - Insulin resistance
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U2 - 10.22159/ajpcr.2016.v9i6.14637
DO - 10.22159/ajpcr.2016.v9i6.14637
M3 - Article
AN - SCOPUS:84994908456
SN - 0974-2441
VL - 9
SP - 331
EP - 333
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - 6
ER -