Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats

Richard E. Coggeshall; Susan M. Carlton

doi:10.1016/j.neulet.2003.09.045

Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats

Richard E. Coggeshall, Susan M. Carlton

Research output: Contribution to journal › Article › peer-review

Abstract

Substance P (SP) is released peripherally from nociceptive terminals and has a direct effect on vascular cells. The present study suggests an indirect effect as well. In normal rats and rats with one hindpaw inflamed for 48 h following intraplantar injection of complete Freund's adjuvant, neurokinin 1 (NK1) receptors were immunohistochemically localized on postganglionic sympathetic axons. The percentage of NK1-labeled axons in the gray rami from normal rats was 35.0±5.0; in inflamed rats this percentage increased significantly to 49.1±2.3. These data suggest a sensory-sympathetic reflex, where SP activates these peripheral sympathetic receptors with subsequent release of noradrenaline and other compounds to affect vascular cells indirectly. This control is enhanced after inflammation.

Original language	English (US)
Pages (from-to)	197-200
Number of pages	4
Journal	Neuroscience Letters
Volume	353
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2003.09.045
State	Published - Dec 26 2003
Externally published	Yes

Keywords

Inflammation
Pain
Sensory
Substance P

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2003.09.045

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@article{0e7a89baa23f43d2b58c58990147f075,

title = "Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats",

abstract = "Substance P (SP) is released peripherally from nociceptive terminals and has a direct effect on vascular cells. The present study suggests an indirect effect as well. In normal rats and rats with one hindpaw inflamed for 48 h following intraplantar injection of complete Freund's adjuvant, neurokinin 1 (NK1) receptors were immunohistochemically localized on postganglionic sympathetic axons. The percentage of NK1-labeled axons in the gray rami from normal rats was 35.0±5.0; in inflamed rats this percentage increased significantly to 49.1±2.3. These data suggest a sensory-sympathetic reflex, where SP activates these peripheral sympathetic receptors with subsequent release of noradrenaline and other compounds to affect vascular cells indirectly. This control is enhanced after inflammation.",

keywords = "Inflammation, Pain, Sensory, Substance P",

author = "Coggeshall, {Richard E.} and Carlton, {Susan M.}",

note = "Funding Information: The authors thank Vicki Wilson for her excellent secretarial assistance. This work was supported by NIH grants NS11255, NS27910 and NS40700 to S.M.C. and by grants NS10161 and NS40700 to R.E.C. Thank you to Zhixia Ding for her contributions to the immunohistochemistry and electron microscopic analysis.",

year = "2003",

month = dec,

day = "26",

doi = "10.1016/j.neulet.2003.09.045",

language = "English (US)",

volume = "353",

pages = "197--200",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

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T1 - Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats

AU - Coggeshall, Richard E.

AU - Carlton, Susan M.

N1 - Funding Information: The authors thank Vicki Wilson for her excellent secretarial assistance. This work was supported by NIH grants NS11255, NS27910 and NS40700 to S.M.C. and by grants NS10161 and NS40700 to R.E.C. Thank you to Zhixia Ding for her contributions to the immunohistochemistry and electron microscopic analysis.

PY - 2003/12/26

Y1 - 2003/12/26

N2 - Substance P (SP) is released peripherally from nociceptive terminals and has a direct effect on vascular cells. The present study suggests an indirect effect as well. In normal rats and rats with one hindpaw inflamed for 48 h following intraplantar injection of complete Freund's adjuvant, neurokinin 1 (NK1) receptors were immunohistochemically localized on postganglionic sympathetic axons. The percentage of NK1-labeled axons in the gray rami from normal rats was 35.0±5.0; in inflamed rats this percentage increased significantly to 49.1±2.3. These data suggest a sensory-sympathetic reflex, where SP activates these peripheral sympathetic receptors with subsequent release of noradrenaline and other compounds to affect vascular cells indirectly. This control is enhanced after inflammation.

AB - Substance P (SP) is released peripherally from nociceptive terminals and has a direct effect on vascular cells. The present study suggests an indirect effect as well. In normal rats and rats with one hindpaw inflamed for 48 h following intraplantar injection of complete Freund's adjuvant, neurokinin 1 (NK1) receptors were immunohistochemically localized on postganglionic sympathetic axons. The percentage of NK1-labeled axons in the gray rami from normal rats was 35.0±5.0; in inflamed rats this percentage increased significantly to 49.1±2.3. These data suggest a sensory-sympathetic reflex, where SP activates these peripheral sympathetic receptors with subsequent release of noradrenaline and other compounds to affect vascular cells indirectly. This control is enhanced after inflammation.

KW - Inflammation

KW - Pain

KW - Sensory

KW - Substance P

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SP - 197

EP - 200

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats

Abstract

Keywords

ASJC Scopus subject areas

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