Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Aseem Mishra; Anurag Misra; T. Sri Vaishnavi; Chaitanya Thota; Madhvi Gupta; Suryanarayanarao Ramakumar; Virander Singh Chauhan

doi:10.1039/c3cc38982k

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Aseem Mishra, Anurag Misra, T. Sri Vaishnavi, Chaitanya Thota, Madhvi Gupta, Suryanarayanarao Ramakumar, Virander Singh Chauhan

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

Original language	English (US)
Pages (from-to)	2688-2690
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	26
DOIs	https://doi.org/10.1039/c3cc38982k
State	Published - Mar 5 2013
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c3cc38982k

Cite this

@article{fb3442b80e5e42c3a1107b64383fd370,

title = "Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization",

abstract = "hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.",

author = "Aseem Mishra and Anurag Misra and {Sri Vaishnavi}, T. and Chaitanya Thota and Madhvi Gupta and Suryanarayanarao Ramakumar and Chauhan, {Virander Singh}",

year = "2013",

month = mar,

day = "5",

doi = "10.1039/c3cc38982k",

language = "English (US)",

volume = "49",

pages = "2688--2690",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "26",

}

TY - JOUR

T1 - Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

AU - Mishra, Aseem

AU - Misra, Anurag

AU - Sri Vaishnavi, T.

AU - Thota, Chaitanya

AU - Gupta, Madhvi

AU - Ramakumar, Suryanarayanarao

AU - Chauhan, Virander Singh

PY - 2013/3/5

Y1 - 2013/3/5

N2 - hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

AB - hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

UR - http://www.scopus.com/inward/record.url?scp=84874855623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874855623&partnerID=8YFLogxK

U2 - 10.1039/c3cc38982k

DO - 10.1039/c3cc38982k

M3 - Article

C2 - 23435449

AN - SCOPUS:84874855623

SN - 1359-7345

VL - 49

SP - 2688

EP - 2690

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this