Conformational states governing the rates of spontaneous transition mutations

Rahul Mitra, B. Montgomery Pettitt, R. D. Blake

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We report the results of a theoretical study, combining the results of sequence analysis and integral equation structural methods for nucleic acids in aqueous solutions, on the effects of nearest neighbors on the (T.G) mispair in solution, for 12 nearest neighbor contexts. Attempts have been made to classify the structural and energetic effects of the 5′ and 3′ neighbors with respect to the observed spontaneous mutation rates in vertebrates. It is found that 5′ nearest neighbor is probably the most critical structural factor in facilitating or discouraging mutations. Local conformational states correlate with discrimination of bases to be excised in mispairs. Our study confirms the role of the flexibility of the DNA molecule in governing the rates of spontaneous mutations. © 1995 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)169-179
Number of pages11
Issue number2
StatePublished - Aug 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry


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