Conductance of end-plate channels is voltage dependent

D. F. Van Helden; P. W. Gage; O. P. Hamill

doi:10.1016/0304-3940(79)90133-2

Conductance of end-plate channels is voltage dependent

D. F. Van Helden, P. W. Gage, O. P. Hamill

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The amplitude of miniature end-plate currents (MEPCs) and end-plate currents generated by iontophoresis of acetylcholine (ACh) were recorded in voltage-clamped toad sartorius fibres. Single channel conductance was determined from analysis of current fluctuations. In normal solution, but even more so in solutions containing lithium instead of sodium, both the peak conductance during a miniature end-plate current and the conductance of individual end-plate channels varied with membrane potential, becoming less at more hyperpolarized potentials. Single channel conductance was not influenced by membrane potential in solutions containing potassium or caesium instead of sodium. It was concluded that the nature of the ions passing through an end-plate channel influences its conductance.

Original language	English (US)
Pages (from-to)	227-232
Number of pages	6
Journal	Neuroscience Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(79)90133-2
State	Published - Feb 1979
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(79)90133-2

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abstract = "The amplitude of miniature end-plate currents (MEPCs) and end-plate currents generated by iontophoresis of acetylcholine (ACh) were recorded in voltage-clamped toad sartorius fibres. Single channel conductance was determined from analysis of current fluctuations. In normal solution, but even more so in solutions containing lithium instead of sodium, both the peak conductance during a miniature end-plate current and the conductance of individual end-plate channels varied with membrane potential, becoming less at more hyperpolarized potentials. Single channel conductance was not influenced by membrane potential in solutions containing potassium or caesium instead of sodium. It was concluded that the nature of the ions passing through an end-plate channel influences its conductance.",

author = "{Van Helden}, {D. F.} and Gage, {P. W.} and Hamill, {O. P.}",

year = "1979",

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doi = "10.1016/0304-3940(79)90133-2",

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journal = "Neuroscience Letters",

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T1 - Conductance of end-plate channels is voltage dependent

AU - Van Helden, D. F.

AU - Gage, P. W.

AU - Hamill, O. P.

PY - 1979/2

Y1 - 1979/2

N2 - The amplitude of miniature end-plate currents (MEPCs) and end-plate currents generated by iontophoresis of acetylcholine (ACh) were recorded in voltage-clamped toad sartorius fibres. Single channel conductance was determined from analysis of current fluctuations. In normal solution, but even more so in solutions containing lithium instead of sodium, both the peak conductance during a miniature end-plate current and the conductance of individual end-plate channels varied with membrane potential, becoming less at more hyperpolarized potentials. Single channel conductance was not influenced by membrane potential in solutions containing potassium or caesium instead of sodium. It was concluded that the nature of the ions passing through an end-plate channel influences its conductance.

AB - The amplitude of miniature end-plate currents (MEPCs) and end-plate currents generated by iontophoresis of acetylcholine (ACh) were recorded in voltage-clamped toad sartorius fibres. Single channel conductance was determined from analysis of current fluctuations. In normal solution, but even more so in solutions containing lithium instead of sodium, both the peak conductance during a miniature end-plate current and the conductance of individual end-plate channels varied with membrane potential, becoming less at more hyperpolarized potentials. Single channel conductance was not influenced by membrane potential in solutions containing potassium or caesium instead of sodium. It was concluded that the nature of the ions passing through an end-plate channel influences its conductance.

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VL - 11

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JO - Neuroscience Letters

JF - Neuroscience Letters

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Conductance of end-plate channels is voltage dependent

Abstract

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