Abstract
Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy associated with anticancer drug development, the repositioning of established non-cancer drugs for new oncology indications has emerged as an increasingly attractive approach to addressing the unmet cancer-related medical need. With the rapid development of bioinformatics, chemoinformatics as well as high-performance computing, drug repositioning is becoming more intentional than ever, and a significant surge of computational approaches has been well established to greatly facilitate drug repositioning for cancer treatment. In this review, we provide a brief overview of recent advances in the computational drug repositioning for anticancer applications with a specific emphasis on repositioning of non-cancer drugs by use of various computational approaches.
Original language | English (US) |
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Pages (from-to) | 767-775 |
Number of pages | 9 |
Journal | Current topics in medicinal chemistry |
Volume | 15 |
Issue number | 8 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Anticancer drugs
- Cancer therapeutics
- Computational drug repositioning
- Drug discovery
- Drug repositioning
- Drug repurposing
ASJC Scopus subject areas
- Drug Discovery