Complex-specific immunoglobulin M antibody patterns in humans infected with alphaviruses

C. H. Calisher, A. O. El-Kafrawi, M. I. Al-Deen Mahmud, A. P. Travassos da Rosa, C. R. Bartz, M. Brummer-Korvenkontio, S. Haksohusodo, W. Suharyono

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Sera from humans with serologically confirmed eastern equine encephalitis, western equine encephalitis, Pogosta (Ockelbo), Mayaro, Ross River, and chikungunya virus infections were tested by immunoglobulin M (IgM) antibody capture enzyme immunoassay. Diagnostically useful IgM antibody titers were detected, and selected sera with high IgM antibody titers were tested for IgM antibody with nine heterologous alphaviruses. The results provide evidence for the complex specificity of IgM antibody and indicate the usefulness of this test in both individual cases and epidemic situations.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalJournal of Clinical Microbiology
Issue number1
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)


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