TY - JOUR
T1 - Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30 and VP24 proteins
AU - Bukreyev, A. A.
AU - Belanov, E. F.
AU - Blinov, V. M.
AU - Netesov, S. V.
PY - 1995
Y1 - 1995
N2 - Nucleotide sequences of the genes 5 and 6 of the Marburg virus, Popp strain, were determined. ORFs encoding polypeptides VP30 (281 a.a., MW 32,640) and VP24 (253 a.a., MW 28,621) were found. The putative transcription start and stop signals for viral RNA-dependent RNA polymerase were revealed for both genes. Overlapping of genes 5 and 6 was shown. The deduced amino acid sequences of VP30 and VP24 proteins displayed significant homology with the analogous proteins of another filovirus, the Ebola virus (33% and 37%, respectively). The VP24 appeared to have a hydrophobic amino acid composition; content of hydrophobic amino acids was 40,7%. Model of VP24 location in the virion was suggested.
AB - Nucleotide sequences of the genes 5 and 6 of the Marburg virus, Popp strain, were determined. ORFs encoding polypeptides VP30 (281 a.a., MW 32,640) and VP24 (253 a.a., MW 28,621) were found. The putative transcription start and stop signals for viral RNA-dependent RNA polymerase were revealed for both genes. Overlapping of genes 5 and 6 was shown. The deduced amino acid sequences of VP30 and VP24 proteins displayed significant homology with the analogous proteins of another filovirus, the Ebola virus (33% and 37%, respectively). The VP24 appeared to have a hydrophobic amino acid composition; content of hydrophobic amino acids was 40,7%. Model of VP24 location in the virion was suggested.
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M3 - Article
C2 - 7773195
AN - SCOPUS:0029553624
SN - 1039-9712
VL - 35
SP - 605
EP - 613
JO - Biochemistry and Molecular Biology International
JF - Biochemistry and Molecular Biology International
IS - 3
ER -