Complement depletion affects demyelination and inflammation in experimental allergic neuritis

Francine J. Vriesendorp, Robyn E. Flynn, Miguel A. Pappolla, Carol L. Koski

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The effect of systemic complement depletion by cobra venom factor (CVF) on experimental allergic neuritis (BAN) was studied in rats immunized with variable amounts of bovine peripheral nerve myelin. Low-dose myelin EAN rats treated with CVF i.p. (n = 10) had lower clinical scores (0.3 ± 0.7 vs. 1.1 ± 1.1), less demyelination (0.4 ± 0.8 vs. 1.9 ± 1.1) and inflammation (0.6 ± 1.2 vs. 2 ± 1) than EAN animals treated with i.p. saline (n = 10). Endoneurial infiltrates had fewer EDI-positive (phagocytic) macrophages (if0.4 ± 0.5 vs.> 1.6 ± 1.1) and CD11bc-positive (expressing iC3b receptor or CR3) cells (1 ± 0.8 vs. 2.5 ± 0.8) (mean ± S.D.) detected by immunocytochemistry. This effect was partially abrogated by immunizing animals with a higher dose of myelin. Our studies suggest that complement may play a role in the recruitment of macrophages into the endoneurium and in opsonizing myelin for phagocytosis.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalJournal of Neuroimmunology
Issue number2
StatePublished - May 1995
Externally publishedYes


  • Complement
  • Demyelination
  • Experimental allergic neuritis
  • Macrophage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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