Comparison of symptoms of influenza A with abacavir-associated hypersensitivity reaction

Philip Keiser, Naiel Nassar, Daniel Skiest, Charla Andrews, Beena Yazdani, Alice White, Seth Hetherington

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Differentiation between abacavir hypersensitivity and viral respiratory infections is problematic. Fifteen cases of abacavir hypersensitivity were matched to 30 controls with culture proven influenza A with no abacavir exposure. Rash was associated with hypersensitivity (odds ratio [OR]=13.1, P=0.02) as was the presence of nausea (OR=30, P<0.001), vomiting (OR=17.1, P=0.001) or diarrhoea (OR=22, P<0.001). The number of gastrointestinal symptoms was also predictive of hypersensitivity reaction (P<0.001). Respiratory symptoms (cough, sore throat, or dyspnoea) were not associated with abacavir hypersensitivity (OR=0.08, P=0.001). Multivariate analysis confirmed the following associations for abacavir hypersensitivity: the number of gastrointestinal symptoms (OR=8.6, P=0.0032), cough (OR=0.039, P=0.02) and rash (OR=16.9, P=0.07). Abacavir hypersensitivity is strongly associated with gastrointestinal (GI) symptoms. Cough without GI symptoms is associated with influenza.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalInternational Journal of STD and AIDS
Issue number7
StatePublished - Jul 1 2003
Externally publishedYes


  • Allergy
  • Antiretroviral therapy
  • Hypersensitivity
  • Influenza

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases


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