Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia

Linda M. Paulson; Peter Martin; Carol L. Nilsson; Elisabeth Ljung; Ann Brinkmalm-Westman; Kaj Blennow; Pia Davidsson

Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia

Linda M. Paulson, Peter Martin, Carol L. Nilsson, Elisabeth Ljung, Ann Brinkmalm-Westman, Kaj Blennow, Pia Davidsson

Research output: Contribution to conference › Paper › peer-review

Abstract

The comparative analysis of protein in schizophrenia using two-dimensional gel-electrophoresis in combination with mass spectrometry (MS) was discussed. The changes in the glutamate transmission played an important role in the pathophysiology of schizophrenia. The protein expressions were compared in thalamus in eight MK-801 treated rats and eight controls. Results show that MK-801 treatment of rats represents a model useful in search for antipsychotic compounds which diminishes the development of biochemical disturbances in schizophrenia.

Original language	English (US)
Pages	217-218
Number of pages	2
State	Published - 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: Jun 2 2002 → Jun 6 2002

Other

Other	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	6/2/02 → 6/6/02

ASJC Scopus subject areas

Spectroscopy

Cite this

Paulson, L. M., Martin, P., Nilsson, C. L., Ljung, E., Brinkmalm-Westman, A., Blennow, K., & Davidsson, P. (2002). Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia. 217-218. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia. / Paulson, Linda M.; Martin, Peter; Nilsson, Carol L. et al.
2002. 217-218 Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Research output: Contribution to conference › Paper › peer-review

Paulson, LM, Martin, P, Nilsson, CL, Ljung, E, Brinkmalm-Westman, A, Blennow, K & Davidsson, P 2002, 'Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02 - 6/6/02 pp. 217-218.

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abstract = "The comparative analysis of protein in schizophrenia using two-dimensional gel-electrophoresis in combination with mass spectrometry (MS) was discussed. The changes in the glutamate transmission played an important role in the pathophysiology of schizophrenia. The protein expressions were compared in thalamus in eight MK-801 treated rats and eight controls. Results show that MK-801 treatment of rats represents a model useful in search for antipsychotic compounds which diminishes the development of biochemical disturbances in schizophrenia.",

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AU - Brinkmalm-Westman, Ann

AU - Blennow, Kaj

AU - Davidsson, Pia

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AB - The comparative analysis of protein in schizophrenia using two-dimensional gel-electrophoresis in combination with mass spectrometry (MS) was discussed. The changes in the glutamate transmission played an important role in the pathophysiology of schizophrenia. The protein expressions were compared in thalamus in eight MK-801 treated rats and eight controls. Results show that MK-801 treatment of rats represents a model useful in search for antipsychotic compounds which diminishes the development of biochemical disturbances in schizophrenia.

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ER -

Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia

Abstract

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ASJC Scopus subject areas

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