Cogan’s syndrome

Rex M. McCallum, E. William St Clair, Barton F. Haynes

Research output: Chapter in Book/Report/Conference proceedingChapter


The hallmarks of Cogan’s syndrome (CS) are interstitial keratitis (IK) and vestibuloauditory dysfunction. The history of CS reflects a growing awareness of its potential for causing not only eye and ear disease, but also complex systemic manifestations. In 1945, David G. Cogan, an ophthalmologist at the Harvard Medical School, reported four cases of recurrent nonsyphilitic IK and vestibuloauditory symptoms (1). These cases were similar to a patient who had been described in 1934 with IK and Meniere’s disease (2). Cogan was later credited with the first description of this disorder, which now bears his name (1).

Original languageEnglish (US)
Title of host publicationInflammatory Diseases of Blood Vessels
PublisherCRC Press
Number of pages19
ISBN (Electronic)9780824746599
ISBN (Print)9780824703844
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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