Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report

Janine S. Sabino, Mariene R. Amorim, William M. de Souza, Lia F. Marega, Luciana S. Mofatto, Daniel A. Toledo-Teixeira, Julia Forato, Rodrigo G. Stabeli, Maria Laura Costa, Fernando R. Spilki, Ester C. Sabino, Nuno R. Faria, Bruno D. Benites, Marcelo Addas-Carvalho, Raquel S.B. Stucchi, Dewton M. Vasconcelos, Scott C. Weaver, Fabiana Granja, José Luiz Proenca-Modena, Maria Marluce Dos S. Vilela

Research output: Contribution to journalArticlepeer-review

Abstract

Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immuno-suppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.

Original languageEnglish (US)
Article number1042
JournalViruses
Volume14
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • IgA
  • NFκB-deficiency
  • breast milk
  • immunosuppression
  • persistent SARS-CoV-2 infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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