Citrulline does not relax isolated rat and rabbit vessels

Stephen Marx; Yuri Vedernikov; George R. Saade; Robert E. Garfield

doi:10.1038/sj.bjp.0703372

Citrulline does not relax isolated rat and rabbit vessels

Stephen Marx, Yuri Vedernikov, George R. Saade, Robert E. Garfield

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

1. The study was prompted by the report of Ruiz E. and Tejerina T., describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. 2. We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. 3. No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10^-12 to 10^-3 M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10^-6 M) relaxed vascular tissues. 4. This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle.

Original language	English (US)
Pages (from-to)	713-716
Number of pages	4
Journal	British Journal of Pharmacology
Volume	130
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjp.0703372
State	Published - 2000

Keywords

3-Morpholinosydnonimine hydrochloride (SIN-1)
L-arginine
L-citrulline
Relaxation
Vascular smooth muscle

ASJC Scopus subject areas

Pharmacology

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10.1038/sj.bjp.0703372

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title = "Citrulline does not relax isolated rat and rabbit vessels",

abstract = "1. The study was prompted by the report of Ruiz E. and Tejerina T., describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. 2. We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. 3. No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10-12 to 10-3 M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10-6 M) relaxed vascular tissues. 4. This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle.",

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T1 - Citrulline does not relax isolated rat and rabbit vessels

AU - Marx, Stephen

AU - Vedernikov, Yuri

AU - Saade, George R.

AU - Garfield, Robert E.

PY - 2000

Y1 - 2000

N2 - 1. The study was prompted by the report of Ruiz E. and Tejerina T., describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. 2. We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. 3. No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10-12 to 10-3 M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10-6 M) relaxed vascular tissues. 4. This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle.

AB - 1. The study was prompted by the report of Ruiz E. and Tejerina T., describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. 2. We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. 3. No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10-12 to 10-3 M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10-6 M) relaxed vascular tissues. 4. This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle.

KW - 3-Morpholinosydnonimine hydrochloride (SIN-1)

KW - L-arginine

KW - L-citrulline

KW - Relaxation

KW - Vascular smooth muscle

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EP - 716

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

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ER -

Citrulline does not relax isolated rat and rabbit vessels

Abstract

Keywords

ASJC Scopus subject areas

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