Circumvention of human tumor drug resistance

Kevin J. Scanlon, Lawrence C. Sowers

Research output: Contribution to journalArticlepeer-review


A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.

Original languageEnglish (US)
Pages (from-to)701
Number of pages1
JournalBiotechnology Advances
Issue number3-4
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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