Circumvention of human tumor drug resistance

Kevin J. Scanlon; Lawrence C. Sowers

doi:10.1016/s0734-9750(97)87647-1

Circumvention of human tumor drug resistance

Research output: Contribution to journal › Article › peer-review

Abstract

A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.

Original language	English (US)
Pages (from-to)	701
Number of pages	1
Journal	Biotechnology Advances
Volume	15
Issue number	3-4
DOIs	https://doi.org/10.1016/s0734-9750(97)87647-1
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1016/s0734-9750(97)87647-1

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title = "Circumvention of human tumor drug resistance",

abstract = "A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.",

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year = "1997",

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language = "English (US)",

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T1 - Circumvention of human tumor drug resistance

AU - Scanlon, Kevin J.

AU - Sowers, Lawrence C.

PY - 1997

Y1 - 1997

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AB - A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.

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DO - 10.1016/s0734-9750(97)87647-1

M3 - Article

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SN - 0734-9750

VL - 15

SP - 701

JO - Biotechnology Advances

JF - Biotechnology Advances

IS - 3-4

ER -

Circumvention of human tumor drug resistance

Abstract

ASJC Scopus subject areas

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