TY - JOUR
T1 - Chronobiologic considerations in human growth hormone therapy
AU - Matustik, M. Cassandra
AU - Furlanetto, Richard W.
AU - Meyer, Walter J.
N1 - Funding Information:
From the Department of Pediatrics, University of Texas Medical Branch. Supported by Grant RR-73 from the General Clinical Research Center Program of the Division of Resources, National Institutes of Health; and by the Department of Pediatrics, University of Texas Medical Branch. Reprint requests: Walter J. Meyer I11, M.D., Department of Pediatrics, Division of Endocrinology, University of Texas Medical Branch, Galveston, TX 77550.
PY - 1983/10
Y1 - 1983/10
N2 - Because there is a striking diurnal variation in serum growth hormone concentration, the effect of the time of administration of growth hormone replacement therapy was examined in nine children with growth hormone deficiency. No differences in growth rate or somatomedin concentration were noted between morning and evening treatment schedules. Somatomedin concentrations were not constant over the 48 hours between growth hormone injections, and the peak value occurred approximately 24 hours after the growth hormone injection. Thus the timing of growth hormone administration is not an important aspect of growth hormone therapy.
AB - Because there is a striking diurnal variation in serum growth hormone concentration, the effect of the time of administration of growth hormone replacement therapy was examined in nine children with growth hormone deficiency. No differences in growth rate or somatomedin concentration were noted between morning and evening treatment schedules. Somatomedin concentrations were not constant over the 48 hours between growth hormone injections, and the peak value occurred approximately 24 hours after the growth hormone injection. Thus the timing of growth hormone administration is not an important aspect of growth hormone therapy.
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U2 - 10.1016/S0022-3476(83)80580-0
DO - 10.1016/S0022-3476(83)80580-0
M3 - Article
C2 - 6684678
AN - SCOPUS:0020553215
SN - 0022-3476
VL - 103
SP - 543
EP - 546
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 4
ER -