Chronic granulomatous disease involving the central nervous system

David H. Walker, Gretchen Okiye

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Two male sibling infants died following a short course of lethargy and obtundation after a lifelong history of persistent, unrelenting diarrhea. Postmortem examination revealed extensive necrosis and early granuloma formation in the liver, spleen, lungs, and lymph nodes as well as in the central nervous system. To our knowledge, this fulminant clinical course, with documentation of granulomatous CNS lesions, has not been reported in patients with chronic granulomatous disease of childhood..

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalFetal and Pediatric Pathology
Issue number2
StatePublished - 1983
Externally publishedYes


  • Central nervous system
  • Choroid plexus
  • Chronic granulomatous disease
  • Granuloma
  • Meningoencephalitis
  • Phagocyte

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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