Chemokine analogues show suitable stability for development as microbicides

Fabrice Cerini, Alan Landay, Carolyne Gichinga, Michael M. Lederman, Rebecca Flyckt, David Starte, Robin E. Offord, François Le Gal, Oliver Hanley

Research output: Contribution to journalArticlepeer-review


New prevention strategies are urgently needed to slow the spread of the HIV/AIDS pandemic, and in the absence of an effective vaccine, there is hope that "microbicides"-HIV inhibitors applied to mucosal surfaces before sexual intercourse-may be able to make an impact. Because developing countries are at the center of the epidemic, affordability and stability during storage are key criteria for candidate microbicides. Furthermore, because formulation strategies that provide long-duration protection after a single dose may enhance acceptability and compliance, stability in the vaginal environment and in the presence of semen should also be considered. PSC-RANTES, a human chemokine analog, has shown promise as a candidate microbicide, but because it contains nonnatural structures that necessitate chemical synthesis steps, it is not suitable for production at a feasible cost and scale for general distribution in developing countries. We have recently developed 2 new fully recombinant chemokine analogs, 5P12-RANTES and 6P4-RANTES, which show equivalent anti-HIV activity to PSCRANTES. In this study, we tested the stability of these molecules under conditions related to use as microbicides. Our results suggest that stability issues will not present a major obstacle to the further development of these promising molecules as microbicides.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number5
StatePublished - Dec 2008
Externally publishedYes


  • CCR5
  • Chemokine
  • Microbicide
  • Prevention
  • Stability

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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