TY - JOUR
T1 - Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C
AU - Litvak, David A.
AU - Iseki, Hideaki
AU - Evers, B. Mark
AU - Greeley, George H.
AU - Hellmich, Mark R.
AU - Iwase, Kazuhiro
AU - Balasubramaniam, Ambikaipakan
AU - Townsend, Courtney M.
N1 - Funding Information:
Manuscript receive d June 4, 1998; accepte d October 8, 1998. From the De partme nt of Surgery, The Unive rsity of Texas Medical Branch, Galve ston, Texa; asdntheUnive rsity of Cincinnati Medical Center, Cincinnati, Ohio. Daid vA. Litvak was a visiting scientist from the Universtiy California, Dais-Evast Bay Oakland, California. Presente d, in part, at the Association for Academic Surgery meeting(November6± 8,1997)inDallas,Texas. This work was funded by grants from the National Institutes of Health (PO1 DK36085, T32-DK07633, and GM47122) , and a grant from Biomeasure Inc. (Medford, Massachusetts). Address for reprint requests: Dr. Courtney M. Townsend, Jr., De partme nt of Surgery, The Unive rsity of TexaMsdical Beranch, 301 Unive rsity Boulevard, Galveston, Texa77s5550527-.
PY - 1999
Y1 - 1999
N2 - Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.
AB - Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.
KW - Intestinal absorption
KW - PYY analog
KW - Peptide YY
KW - Proabsorptive agent
UR - http://www.scopus.com/inward/record.url?scp=0033049952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033049952&partnerID=8YFLogxK
U2 - 10.1023/A:1026686214004
DO - 10.1023/A:1026686214004
M3 - Article
C2 - 10080163
AN - SCOPUS:0033049952
SN - 0163-2116
VL - 44
SP - 643
EP - 648
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 3
ER -