TY - JOUR
T1 - Characterization of triniti virus supports its reclassification in the family peribunyaviridae
AU - Lima, Juliana Abreu
AU - Neto, Joaquim Pinto Nunes
AU - Castro, Karoline Silva
AU - da Rosa, Amélia Paes de Andrade Travassos
AU - Tesh, Robert
AU - Nunes, Márcio Roberto Teixeira
AU - Popov, Vsevolod Leonidovich
AU - Vasilakis, Nikos
AU - Guzman, Hilda
AU - Widen, Steven
AU - da Silva, Sandro Patroca
AU - Medeiros, Daniele Barbosa de Almeida
AU - Cardoso, Jedson Ferreira
AU - Martins, Lívia Carício
AU - Azevedo, Raimunda do Socorro da Silva
AU - Vasconcelos, Pedro Fernando da Costa
AU - Chiang, Jannifer Oliveira
N1 - Publisher Copyright:
© 2019 The Authors.
PY - 2019/2
Y1 - 2019/2
N2 - Triniti virus (TNTV) has been isolated in Trinidad and Tobago and in Brazil. To date little is known about this virus, which is classified as an ungrouped virus within the family Togaviridae. Here, three isolates of TNTV were characterized both genetically and antigenically. The genome was shown to contain three RNA segments: small (S), medium (M) and large (L). Genome organization, protein sizes and protein motifs were similar to those of viruses in the genus Orthobunyavirus, family Peribunyaviridae. Antigenic reactivity revealed the three TNTV isolates to be closely related, but no serologic cross-reaction with other orthobunyaviruses. Morphological observation by transmission electron microscopy indicated that virus size and symmetry were compatible with those of viruses in the family Peribunyaviridae. Our serological, morphological and molecular results support the taxonomic reclassification of TNTV as a member of the genus Orthobunyavirus, family Peribunyaviridae.
AB - Triniti virus (TNTV) has been isolated in Trinidad and Tobago and in Brazil. To date little is known about this virus, which is classified as an ungrouped virus within the family Togaviridae. Here, three isolates of TNTV were characterized both genetically and antigenically. The genome was shown to contain three RNA segments: small (S), medium (M) and large (L). Genome organization, protein sizes and protein motifs were similar to those of viruses in the genus Orthobunyavirus, family Peribunyaviridae. Antigenic reactivity revealed the three TNTV isolates to be closely related, but no serologic cross-reaction with other orthobunyaviruses. Morphological observation by transmission electron microscopy indicated that virus size and symmetry were compatible with those of viruses in the family Peribunyaviridae. Our serological, morphological and molecular results support the taxonomic reclassification of TNTV as a member of the genus Orthobunyavirus, family Peribunyaviridae.
KW - Arbovirus
KW - Peribunyaviridae
KW - Phylogenetic analysis
KW - Serologic tests
KW - Triniti virus
KW - Ultrastructure
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U2 - 10.1099/jgv.0.001196
DO - 10.1099/jgv.0.001196
M3 - Article
C2 - 30547856
AN - SCOPUS:85061123503
SN - 0022-1317
VL - 100
SP - 137
EP - 144
JO - Journal of General Virology
JF - Journal of General Virology
IS - 2
M1 - 001196
ER -