Characterization of the changuinola serogroup viruses (Reoviridae: Orbivirus)

A. P.A. Travassos Da Rosa; R. B. Tesh; F. P. Pinheiro; J. F.S. Travassos Da Rosa; P. H. Peralta; D. L. Knudson

doi:10.1159/000149501

Characterization of the changuinola serogroup viruses (Reoviridae: Orbivirus)

A. P.A. Travassos Da Rosa, R. B. Tesh, F. P. Pinheiro, J. F.S. Travassos Da Rosa, P. H. Peralta, D. L. Knudson

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.

Original language	English (US)
Pages (from-to)	38-49
Number of pages	12
Journal	Intervirology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1159/000149501
State	Published - 1984
Externally published	Yes

Keywords

Changuinola serogroup
Double-stranded RNA
Orbivirus
Serology
Taxonomy

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1159/000149501

Cite this

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title = "Characterization of the changuinola serogroup viruses (Reoviridae: Orbivirus)",

abstract = "The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.",

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T1 - Characterization of the changuinola serogroup viruses (Reoviridae: Orbivirus)

AU - Travassos Da Rosa, A. P.A.

AU - Tesh, R. B.

AU - Pinheiro, F. P.

AU - Travassos Da Rosa, J. F.S.

AU - Peralta, P. H.

AU - Knudson, D. L.

PY - 1984

Y1 - 1984

N2 - The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.

AB - The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.

KW - Changuinola serogroup

KW - Double-stranded RNA

KW - Orbivirus

KW - Serology

KW - Taxonomy

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Characterization of the changuinola serogroup viruses (Reoviridae: Orbivirus)

Abstract

Keywords

ASJC Scopus subject areas

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