Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets

Michael B. Martinez; Silvia M. Pulido; Thomas Krick; Lee Ann Higgins; Bruce Witthuhn; Michael Flickinger; Mark R. Emmett; Alan G. Marshall; Gary L. Nelsestuen

Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets

Michael B. Martinez, Silvia M. Pulido, Thomas Krick, Lee Ann Higgins, Bruce Witthuhn, Michael Flickinger, Mark R. Emmett, Alan G. Marshall, Gary L. Nelsestuen

Research output: Contribution to conference › Paper › peer-review

Abstract

The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.

Original language	English (US)
Pages	345-346
Number of pages	2
State	Published - 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: Jun 2 2002 → Jun 6 2002

Other

Other	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	6/2/02 → 6/6/02

ASJC Scopus subject areas

Spectroscopy

Cite this

Martinez, M. B., Pulido, S. M., Krick, T., Higgins, L. A., Witthuhn, B., Flickinger, M., Emmett, M. R., Marshall, A. G., & Nelsestuen, G. L. (2002). Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets. 345-346. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets. / Martinez, Michael B.; Pulido, Silvia M.; Krick, Thomas et al.
2002. 345-346 Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Research output: Contribution to conference › Paper › peer-review

Martinez, MB, Pulido, SM, Krick, T, Higgins, LA, Witthuhn, B, Flickinger, M, Emmett, MR, Marshall, AG & Nelsestuen, GL 2002, 'Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02 - 6/6/02 pp. 345-346.

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abstract = "The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.",

author = "Martinez, {Michael B.} and Pulido, {Silvia M.} and Thomas Krick and Higgins, {Lee Ann} and Bruce Witthuhn and Michael Flickinger and Emmett, {Mark R.} and Marshall, {Alan G.} and Nelsestuen, {Gary L.}",

year = "2002",

language = "English (US)",

pages = "345--346",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

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T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

AU - Martinez, Michael B.

AU - Pulido, Silvia M.

AU - Krick, Thomas

AU - Higgins, Lee Ann

AU - Witthuhn, Bruce

AU - Flickinger, Michael

AU - Emmett, Mark R.

AU - Marshall, Alan G.

AU - Nelsestuen, Gary L.

PY - 2002

Y1 - 2002

N2 - The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.

AB - The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.

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Y2 - 2 June 2002 through 6 June 2002

ER -

Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets

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ASJC Scopus subject areas

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