Characterization of antiviral activity of benzamide derivative AH0109 against HIV-1 infection

Liyu Chen, Zhujun Ao, Kallesh Danappa Jayappa, Gary Kobinger, Shuiping Liu, Guojun Wu, Mark A. Wainberg, Xiaojian Yao

Research output: Contribution to journalArticlepeer-review


In the absence of an effective vaccine against HIV-1 infection, anti-HIV-1 strategies play a major role in disease control. However, the rapid emergence of drug resistance against all currently used anti-HIV-1 molecules necessitates the development of new antiviral molecules and/or strategies against HIV-1 infection. In this study, we have identified a benzamide derivative named AH0109 that exhibits potent anti-HIV-1 activity at an 50% effective concentration of 0.7 Min HIV-1-susceptible CD4 C8166 T cells. Mechanistic analysis revealed that AH0109 significantly inhibits both HIV-1 reverse transcription and viral cDNA nuclear import. Furthermore, our infection experiments indicated that AH0109 is capable of disrupting the replication of HIV-1 strains that are resistant to the routinely used anti-HIV-1 drugs zidovudine, lamivudine, nevirapine, and raltegravir. Together, these findings provide evidence for a newly identified antiviral molecule that can potentially be developed as an anti-HIV-1 agent.

Original languageEnglish (US)
Pages (from-to)3547-3554
Number of pages8
JournalAntimicrobial agents and chemotherapy
Issue number8
StatePublished - Aug 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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