Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil

Amber R. Engel; Pedro F. C Vasconcelos; Monica A. McArthur; Alan D.T. Barrett

doi:10.1016/j.vaccine.2006.01.009

Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil

Amber R. Engel, Pedro F. C Vasconcelos, Monica A. McArthur, Alan D.T. Barrett

Pathology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.

Original language	English (US)
Pages (from-to)	2803-2809
Number of pages	7
Journal	Vaccine
Volume	24
Issue number	15
DOIs	https://doi.org/10.1016/j.vaccine.2006.01.009
State	Published - Apr 5 2006

Keywords

17DD vaccine
Vaccine-associated adverse events
YF-VAVD
Yellow fever

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/j.vaccine.2006.01.009

Cite this

@article{54b2995506684b78b90401b0c6ca53e0,

title = "Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil",

abstract = "Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.",

keywords = "17DD vaccine, Vaccine-associated adverse events, YF-VAVD, Yellow fever",

author = "Engel, {Amber R.} and {C Vasconcelos}, {Pedro F.} and McArthur, {Monica A.} and Barrett, {Alan D.T.}",

note = "Funding Information: A. Engel was supported by the NIH T32 Training Grant in Emerging and Tropical Infectious Diseases (AI 7526). P.F.C. Vasconcelos was supported by Lancet International Fellowship Award and CNPq (process 401349/2004-7). We would like to thank M.R. Holbrook for critical reading of the manuscript and T. Monath for providing the 17DD-Brazil batch 182A vaccine used in these studies.",

year = "2006",

month = apr,

day = "5",

doi = "10.1016/j.vaccine.2006.01.009",

language = "English (US)",

volume = "24",

pages = "2803--2809",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "15",

}

TY - JOUR

T1 - Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil

AU - Engel, Amber R.

AU - C Vasconcelos, Pedro F.

AU - McArthur, Monica A.

AU - Barrett, Alan D.T.

N1 - Funding Information: A. Engel was supported by the NIH T32 Training Grant in Emerging and Tropical Infectious Diseases (AI 7526). P.F.C. Vasconcelos was supported by Lancet International Fellowship Award and CNPq (process 401349/2004-7). We would like to thank M.R. Holbrook for critical reading of the manuscript and T. Monath for providing the 17DD-Brazil batch 182A vaccine used in these studies.

PY - 2006/4/5

Y1 - 2006/4/5

N2 - Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.

AB - Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.

KW - 17DD vaccine

KW - Vaccine-associated adverse events

KW - YF-VAVD

KW - Yellow fever

UR - http://www.scopus.com/inward/record.url?scp=33644904308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644904308&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2006.01.009

DO - 10.1016/j.vaccine.2006.01.009

M3 - Article

C2 - 16464518

AN - SCOPUS:33644904308

SN - 0264-410X

VL - 24

SP - 2803

EP - 2809

JO - Vaccine

JF - Vaccine

IS - 15

ER -

Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this