TY - JOUR
T1 - Changes in nutritional status associated with obstructive jaundice and biliary drainage in rats
AU - Gouma, D. J.
AU - Roughneen, P. T.
AU - Kumar, S.
AU - Moody, F. G.
AU - Rowlands, B. J.
PY - 1986
Y1 - 1986
N2 - Effect of bile duct ligation (BDL) and internal biliary drainage on food intake and nutritional status was studied in rats and compared with sham and pair-fed animals. During week 1, food intake of BDL animals was reduced (p < 0.05), resulting in weight loss (p < 0.05). In weeks 2 and 3, food intake, nitrogen balance, and weight gain were similar in all groups. Internal biliary drainage or sham operation after 3 wk produced transient changes in food intake and N2 balance. Serum albumin fell in all groups, returned to normal in sham (3.2 ± 0.1 g/dl) and pair-fed (3.1 ± 0.1 g/dl), but persisted in BDL rats (2.4 ± 0.2 g/dl, p < 0.001). Jaundice was associated with anemia. Although BDL produces transient changes in food intake, weight gain, and N2 balance, anorexia and malnutrition are not features of this animal model. Nutritional risk factors associated with hyperbilirubinemia are probably due to changes in intermediary metabolism.
AB - Effect of bile duct ligation (BDL) and internal biliary drainage on food intake and nutritional status was studied in rats and compared with sham and pair-fed animals. During week 1, food intake of BDL animals was reduced (p < 0.05), resulting in weight loss (p < 0.05). In weeks 2 and 3, food intake, nitrogen balance, and weight gain were similar in all groups. Internal biliary drainage or sham operation after 3 wk produced transient changes in food intake and N2 balance. Serum albumin fell in all groups, returned to normal in sham (3.2 ± 0.1 g/dl) and pair-fed (3.1 ± 0.1 g/dl), but persisted in BDL rats (2.4 ± 0.2 g/dl, p < 0.001). Jaundice was associated with anemia. Although BDL produces transient changes in food intake, weight gain, and N2 balance, anorexia and malnutrition are not features of this animal model. Nutritional risk factors associated with hyperbilirubinemia are probably due to changes in intermediary metabolism.
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U2 - 10.1093/ajcn/44.3.362
DO - 10.1093/ajcn/44.3.362
M3 - Article
C2 - 3751957
AN - SCOPUS:0022484307
SN - 0002-9165
VL - 44
SP - 362
EP - 369
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 3
ER -