Challenges and future prospects of antibiotic therapy: From peptides to phages utilization

Santi M. Mandal, Anupam Roy, Ananta K. Ghosh, Tapas K. Hazra, Amit Basak, Octavio L. Franco

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Bacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotics in non-infected patients and in the food industry. New classes of antibiotics with different actions against MDR pathogens need to be developed urgently. In this context, this review focuses on several ways and future directions to search for the next generation of safe and effective antibiotics compounds including antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, lipopolysaccharide, and efflux pump inhibitors to control the infections caused by MDR pathogens.

Original languageEnglish (US)
Article number105
JournalFrontiers in Pharmacology
Volume5 MAY
StatePublished - 2014
Externally publishedYes


  • Antibiotics
  • Infection control
  • Multi-drug-resistant pathogens

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


Dive into the research topics of 'Challenges and future prospects of antibiotic therapy: From peptides to phages utilization'. Together they form a unique fingerprint.

Cite this