Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients

Kathryn Coyne; MacKenzie Purdy; Kathleen O'Leary; Jerome L. Yaklic; Steven R. Lindheim; Leslie A. Appiah

doi:10.3389/fpubh.2014.00246

Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients

Kathryn Coyne, MacKenzie Purdy, Kathleen O'Leary, Jerome L. Yaklic, Steven R. Lindheim, Leslie A. Appiah

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The scope of cancer treatment in women of childbearing age has changed in the last decade. Fertility preservation is no longer an afterthought but central to multi-disciplinary cancer treatment planning and should be addressed due to the cytotoxic effects of cancer therapy. However, oncology patients present as a unique treatment challenge as the physician must balance the urgency of fertility preservation with the risks of delaying cancer therapy. Controlled ovarian stimulation (COS) is routinely applied in assisted reproductive technology but can be contraindicated in women with estrogen-receptor-positive tumors. This paper reviews some of the challenges to consider when using COS and newer stimulation protocols to minimize risks and optimize outcomes in oncofertility patients.

Original language	English (US)
Article number	246
Journal	Frontiers in Public Health
Volume	2
Issue number	DEC
DOIs	https://doi.org/10.3389/fpubh.2014.00246
State	Published - Dec 5 2014
Externally published	Yes

Keywords

Assisted reproduction
Controlled ovarian stimulation
Follicular phase
Luteal phase
Oncofertility

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.3389/fpubh.2014.00246

Cite this

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title = "Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients",

abstract = "The scope of cancer treatment in women of childbearing age has changed in the last decade. Fertility preservation is no longer an afterthought but central to multi-disciplinary cancer treatment planning and should be addressed due to the cytotoxic effects of cancer therapy. However, oncology patients present as a unique treatment challenge as the physician must balance the urgency of fertility preservation with the risks of delaying cancer therapy. Controlled ovarian stimulation (COS) is routinely applied in assisted reproductive technology but can be contraindicated in women with estrogen-receptor-positive tumors. This paper reviews some of the challenges to consider when using COS and newer stimulation protocols to minimize risks and optimize outcomes in oncofertility patients.",

keywords = "Assisted reproduction, Controlled ovarian stimulation, Follicular phase, Luteal phase, Oncofertility",

author = "Kathryn Coyne and MacKenzie Purdy and Kathleen O'Leary and Yaklic, {Jerome L.} and Lindheim, {Steven R.} and Appiah, {Leslie A.}",

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AU - Coyne, Kathryn

AU - Purdy, MacKenzie

AU - O'Leary, Kathleen

AU - Yaklic, Jerome L.

AU - Lindheim, Steven R.

AU - Appiah, Leslie A.

PY - 2014/12/5

Y1 - 2014/12/5

N2 - The scope of cancer treatment in women of childbearing age has changed in the last decade. Fertility preservation is no longer an afterthought but central to multi-disciplinary cancer treatment planning and should be addressed due to the cytotoxic effects of cancer therapy. However, oncology patients present as a unique treatment challenge as the physician must balance the urgency of fertility preservation with the risks of delaying cancer therapy. Controlled ovarian stimulation (COS) is routinely applied in assisted reproductive technology but can be contraindicated in women with estrogen-receptor-positive tumors. This paper reviews some of the challenges to consider when using COS and newer stimulation protocols to minimize risks and optimize outcomes in oncofertility patients.

AB - The scope of cancer treatment in women of childbearing age has changed in the last decade. Fertility preservation is no longer an afterthought but central to multi-disciplinary cancer treatment planning and should be addressed due to the cytotoxic effects of cancer therapy. However, oncology patients present as a unique treatment challenge as the physician must balance the urgency of fertility preservation with the risks of delaying cancer therapy. Controlled ovarian stimulation (COS) is routinely applied in assisted reproductive technology but can be contraindicated in women with estrogen-receptor-positive tumors. This paper reviews some of the challenges to consider when using COS and newer stimulation protocols to minimize risks and optimize outcomes in oncofertility patients.

KW - Assisted reproduction

KW - Controlled ovarian stimulation

KW - Follicular phase

KW - Luteal phase

KW - Oncofertility

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DO - 10.3389/fpubh.2014.00246

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Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients

Abstract

Keywords

ASJC Scopus subject areas

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