Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients

Kathryn Coyne, MacKenzie Purdy, Kathleen O'Leary, Jerome L. Yaklic, Steven R. Lindheim, Leslie A. Appiah

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The scope of cancer treatment in women of childbearing age has changed in the last decade. Fertility preservation is no longer an afterthought but central to multi-disciplinary cancer treatment planning and should be addressed due to the cytotoxic effects of cancer therapy. However, oncology patients present as a unique treatment challenge as the physician must balance the urgency of fertility preservation with the risks of delaying cancer therapy. Controlled ovarian stimulation (COS) is routinely applied in assisted reproductive technology but can be contraindicated in women with estrogen-receptor-positive tumors. This paper reviews some of the challenges to consider when using COS and newer stimulation protocols to minimize risks and optimize outcomes in oncofertility patients.

Original languageEnglish (US)
Article number246
JournalFrontiers in Public Health
Issue numberDEC
StatePublished - Dec 5 2014
Externally publishedYes


  • Assisted reproduction
  • Controlled ovarian stimulation
  • Follicular phase
  • Luteal phase
  • Oncofertility

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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