Central versus peripheral effects of bombesin on the release of gastrointestinal hormones in dogs

Q. ‐H Lu, J. S. Swierczek, X. ‐G Zhu, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This study compared the effects of bombesin given intracerebroventicularly and intravenously on circulating levels of gastrin, pancreatic polypeptide (PP), and cholecystokinin (CCK‐33). Bilateral cannulas were implanted permanently into the lateral cerebral ventricles of five dogs. An intravenous (IV) bolus injection of bombesin (0.25 μg/kg) significantly elevated circulating levels of gastrin, PP, and CCK‐33. Vagotomy inhibited the release of PP that was induced by IV bombesin, but vagotomy did not affect gastrin and CCK‐33 responses. Intracerebroventricular injection of bombesin (5.0 μg) significantly elevated circulating gastrin levels but did not affect circulating levels of CCK‐33 and PP. Vagotomy did not alter gastrin release induced by intracerebroventricular injection of bombesin.

Original languageEnglish (US)
Pages (from-to)553-559
Number of pages7
JournalJournal of Neuroscience Research
Volume16
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • cholecystokinin
  • gastrin
  • intracerebroventricular
  • pancreatic polypeptide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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