Cellular behavior change of macrophage after exposure to nanoparticles

J. K. Hsiao; T. I. Weng; M. F. Tai; Y. F. Chen; Y. H. Wang; C. Y. Yang; J. L. Wang; H. M. Liu

doi:10.1166/jnn.2009.C163

Cellular behavior change of macrophage after exposure to nanoparticles

J. K. Hsiao, T. I. Weng, M. F. Tai, Y. F. Chen, Y. H. Wang, C. Y. Yang, J. L. Wang, H. M. Liu

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Magnetic nanoparticles (MNPs) are few of the nanoparticles used clinically. When MNPs are delivered into human body, they are ingested by macrophages. We evaluated the cellular response of macrophage after MNPs loading. In face of stimulation by lipopolysaccharide, a strong stimulant derived from bacterial cell wall, MNPs loaded macrophage exhibited decreased phagocytic activity and decreased generation of cytokines such as TNF-a, IL-1J3 whereas increased nitric oxide generation was noticed. Although these changes might decrease bactiericidal activity, it also alleviates the risk of senses, a life threatening phenomenon in infection patients. The finding has significant implications on nanoparticle based targeted drug delivery.

Original language	English (US)
Pages (from-to)	1388-1393
Number of pages	6
Journal	Journal of Nanoscience and Nanotechnology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1166/jnn.2009.C163
State	Published - Feb 2009
Externally published	Yes

Keywords

Macrophage
Magnetic nanoparticles
Magnetic resonance imaging.

ASJC Scopus subject areas

Bioengineering
General Chemistry
Biomedical Engineering
General Materials Science
Condensed Matter Physics

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10.1166/jnn.2009.C163

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title = "Cellular behavior change of macrophage after exposure to nanoparticles",

abstract = "Magnetic nanoparticles (MNPs) are few of the nanoparticles used clinically. When MNPs are delivered into human body, they are ingested by macrophages. We evaluated the cellular response of macrophage after MNPs loading. In face of stimulation by lipopolysaccharide, a strong stimulant derived from bacterial cell wall, MNPs loaded macrophage exhibited decreased phagocytic activity and decreased generation of cytokines such as TNF-a, IL-1J3 whereas increased nitric oxide generation was noticed. Although these changes might decrease bactiericidal activity, it also alleviates the risk of senses, a life threatening phenomenon in infection patients. The finding has significant implications on nanoparticle based targeted drug delivery.",

keywords = "Macrophage, Magnetic nanoparticles, Magnetic resonance imaging.",

author = "Hsiao, {J. K.} and Weng, {T. I.} and Tai, {M. F.} and Chen, {Y. F.} and Wang, {Y. H.} and Yang, {C. Y.} and Wang, {J. L.} and Liu, {H. M.}",

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AU - Hsiao, J. K.

AU - Weng, T. I.

AU - Tai, M. F.

AU - Chen, Y. F.

AU - Wang, Y. H.

AU - Yang, C. Y.

AU - Wang, J. L.

AU - Liu, H. M.

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AB - Magnetic nanoparticles (MNPs) are few of the nanoparticles used clinically. When MNPs are delivered into human body, they are ingested by macrophages. We evaluated the cellular response of macrophage after MNPs loading. In face of stimulation by lipopolysaccharide, a strong stimulant derived from bacterial cell wall, MNPs loaded macrophage exhibited decreased phagocytic activity and decreased generation of cytokines such as TNF-a, IL-1J3 whereas increased nitric oxide generation was noticed. Although these changes might decrease bactiericidal activity, it also alleviates the risk of senses, a life threatening phenomenon in infection patients. The finding has significant implications on nanoparticle based targeted drug delivery.

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KW - Magnetic nanoparticles

KW - Magnetic resonance imaging.

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Cellular behavior change of macrophage after exposure to nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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