CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

Ellen J. Beswick; Victor E. Reyes

doi:10.3748/wjg.15.2855

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

Ellen J. Beswick, Victor E. Reyes

Pediatrics

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

Original language	English (US)
Pages (from-to)	2855-2861
Number of pages	7
Journal	World journal of gastroenterology
Volume	15
Issue number	23
DOIs	https://doi.org/10.3748/wjg.15.2855
State	Published - Jun 21 2009

Keywords

CD74
Cancer
Gastrointestinal tract
Helicobacter pylori
Inflammation
Invariant chain

ASJC Scopus subject areas

Gastroenterology

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10.3748/wjg.15.2855

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abstract = "CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.",

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AB - CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

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KW - Gastrointestinal tract

KW - Helicobacter pylori

KW - Inflammation

KW - Invariant chain

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CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

Abstract

Keywords

ASJC Scopus subject areas

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