CD4+ T cell subsets and tax expression in HTLV-1 associated diseases

Nicolas Barros, Jorge Risco, Carlos Rodríguez, Cesar Sánchez, Elsa González, Yuetsu Tanaka, Eduardo Gotuzzo, A. Clinton White, Martin Montes

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalPathogens and Global Health
Issue number4
StatePublished - Jun 2013


  • Foxp3
  • HTLV-1
  • Immunology
  • Regulatory T cells
  • Tax
  • Th1

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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