Abstract
Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.
Original language | English (US) |
---|---|
Article number | 2374 |
Journal | Frontiers in Microbiology |
Volume | 8 |
Issue number | DEC |
DOIs | |
State | Published - Dec 5 2017 |
Externally published | Yes |
Keywords
- Dengue virus
- Flavivirus
- Hepatitis C virus
- Methylation
- Zika virus
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)