TY - JOUR
T1 - Case report
T2 - Guillain-barré syndrome after zika virus infection in Brazil
AU - Do Rosário, Mateus Santana
AU - De Jesus, Pedro Antonio Pereira
AU - Vasilakis, Nikos
AU - Farias, Daniel Santana
AU - Novaes, Marco Antônio Caires
AU - Rodrigues, Sueli Guerreiro
AU - Martins, Lívia Caricio
AU - Da Costa Vasconcelos, Pedro Fernando
AU - Ko, Albert Icksang
AU - Alcântara, Luiz Carlos Junior
AU - De Siqueira, Isadora Cristina
N1 - Publisher Copyright:
© 2016 by The American Society of Tropical Medicine and Hygiene.
PY - 2016/11
Y1 - 2016/11
N2 - Zika virus (ZIKV) is an emerging flavivirus, which has caused a widespread outbreak in the Americas. Shortly after its introduction in 2015, a cluster of cases with Guillain-Barré syndrome was detected in Brazil. Herein, we describe two cases from the city of Salvador, who developed ascending paresis after an acute exanthematous illness. The patients were admitted to the intensive care unit with tetraparesis and cranial nerve palsy, which resolved after intravenous administration of human immunoglobulin. Serological evaluation detected IgM-specific ZIKV antibodies. In regions of Zika virus transmission, health-care workers must be aware of the potential severe neurological complications associated with ZIKV infection and be prepared to provide prompt diagnosis, treatment, and supportive care.
AB - Zika virus (ZIKV) is an emerging flavivirus, which has caused a widespread outbreak in the Americas. Shortly after its introduction in 2015, a cluster of cases with Guillain-Barré syndrome was detected in Brazil. Herein, we describe two cases from the city of Salvador, who developed ascending paresis after an acute exanthematous illness. The patients were admitted to the intensive care unit with tetraparesis and cranial nerve palsy, which resolved after intravenous administration of human immunoglobulin. Serological evaluation detected IgM-specific ZIKV antibodies. In regions of Zika virus transmission, health-care workers must be aware of the potential severe neurological complications associated with ZIKV infection and be prepared to provide prompt diagnosis, treatment, and supportive care.
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U2 - 10.4269/ajtmh.16-0306
DO - 10.4269/ajtmh.16-0306
M3 - Article
C2 - 27645785
AN - SCOPUS:84994314213
SN - 0002-9637
VL - 95
SP - 1157
EP - 1160
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -