Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation

Alice Ferng; Alana Connell; Martha Nunez; Kitsie Johnson; Beth Braunhut; Scott Lick; Ankit Desai; Toshinobu Kazui; Ray Runyan; Zain Khalpey

doi:10.1016/j.athoracsur.2017.03.044

Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation

Alice Ferng, Alana Connell, Martha Nunez, Kitsie Johnson, Beth Braunhut, Scott Lick, Ankit Desai, Toshinobu Kazui, Ray Runyan, Zain Khalpey

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium. Excised CorMatrix from the aorta showed organization of collagen and elastin similar to native aortic tissue.

Original language	English (US)
Pages (from-to)	e239-e241
Journal	Annals of Thoracic Surgery
Volume	104
Issue number	3
DOIs	https://doi.org/10.1016/j.athoracsur.2017.03.044
State	Published - Sep 2017
Externally published	Yes

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.athoracsur.2017.03.044

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title = "Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation",

abstract = "CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium. Excised CorMatrix from the aorta showed organization of collagen and elastin similar to native aortic tissue.",

author = "Alice Ferng and Alana Connell and Martha Nunez and Kitsie Johnson and Beth Braunhut and Scott Lick and Ankit Desai and Toshinobu Kazui and Ray Runyan and Zain Khalpey",

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AU - Ferng, Alice

AU - Connell, Alana

AU - Nunez, Martha

AU - Johnson, Kitsie

AU - Braunhut, Beth

AU - Lick, Scott

AU - Desai, Ankit

AU - Kazui, Toshinobu

AU - Runyan, Ray

AU - Khalpey, Zain

PY - 2017/9

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AB - CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium. Excised CorMatrix from the aorta showed organization of collagen and elastin similar to native aortic tissue.

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Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation

Abstract

ASJC Scopus subject areas

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