Cardiac implantable electronic devices in patients with persistent left superior vena cava—A single center experience

Bahjat Ghazzal, Dean Sabayon, Soroosh Kiani, Angel R. Leon, David Delurgio, Anshul M. Patel, Michael S. Lloyd, Stacy Westerman, Anand Shah, Faisal M. Merchant, Mikhael F. El-Chami

Research output: Contribution to journalArticlepeer-review


Background: There are limited data on cardiac implantable electronic device implantation (CIED) in patients with persistent left superior vena cava (PLSVC). Objective: To describe the outcomes of implanting CIEDs with a focus on cardiac resynchronization therapy (CRT) in patients with PLSVC. Methods: We identified all patients with a PLSVC that underwent CIED implantation from December 2008 until February 2019 at our institution by querying the electronic medical record (n = 34). We then identified controls in a 3:1 fashion (n = 102) by matching on device type (CRT vs non-CRT). Procedure success, complications, fluoroscopy and procedural time were recorded. Outcomes were compared using a two-way analysis of variance test and conditional regression modeling for continuous and categorical variables, respectively. Results: A total of 34 patients with PLSVC underwent 38 procedures. Four patients underwent dual chamber system implantation followed by a subsequent upgrade to CRT. Thirteen patients underwent CRT implantation: one was implanted via the right subclavian while the rest were implanted via the PLSVC. Left ventricular (P =.06). Procedure and fluoroscopy times were significantly higher in the PLSVC as compared with the control group (97.7 vs 66.1 minute, P <.001 and 18.1 minute vs 8.7 minutes, P =.005, respectively). Conclusion: CIED implant in patients with PLSVC is feasible but technically more challenging and appears to be associated with higher risk of right ventricular lead dislodgment.

Original languageEnglish (US)
Pages (from-to)1175-1181
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Issue number5
StatePublished - May 1 2020
Externally publishedYes


  • ICD
  • cardiac implantable electronic devices
  • left ventricular lead
  • pacemakers
  • persistent left superior vena cava

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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