TY - JOUR
T1 - Cardiac Contractility Modulation in Patients with Advanced Heart Failure
T2 - A Comprehensive Review of Literature
AU - Salehin, Salman
AU - Harmouch, Wissam
AU - Yaqub, Maha
AU - Khan, Umer
AU - Merie, Anwar
AU - Salehin, Shahran
AU - Hasan, Syed Mustajab
AU - Khalife, Wissam I.
AU - Sabayon, Muhie Dean
AU - Chatila, Khaled
AU - Raja, Muhammad
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2024/1
Y1 - 2024/1
N2 - Heart failure is a significant cause of morbidity and mortality worldwide. Despite advancements in guideline-directed medical therapy and improvements in device-based therapies, patients with advanced heart failure have high rates of mortality regardless of ejection fraction. For patients with reduced ejection fraction who meet criteria, cardiac resynchronization therapy or implantable cardiac defibrillators are options available to improve outcomes. However, not all heart failure patients meet those criteria. Cardiac contractility modulation is an innovative therapy that serves to improve functional outcomes and quality of life, while also modifying pathologic gene expression and preventing further remodeling. In this article, we aim to discuss the major clinical trials investigating cardiac contractility modulation as a suitable therapy for patients with advanced heart failure.
AB - Heart failure is a significant cause of morbidity and mortality worldwide. Despite advancements in guideline-directed medical therapy and improvements in device-based therapies, patients with advanced heart failure have high rates of mortality regardless of ejection fraction. For patients with reduced ejection fraction who meet criteria, cardiac resynchronization therapy or implantable cardiac defibrillators are options available to improve outcomes. However, not all heart failure patients meet those criteria. Cardiac contractility modulation is an innovative therapy that serves to improve functional outcomes and quality of life, while also modifying pathologic gene expression and preventing further remodeling. In this article, we aim to discuss the major clinical trials investigating cardiac contractility modulation as a suitable therapy for patients with advanced heart failure.
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U2 - 10.1016/j.cpcardiol.2023.102102
DO - 10.1016/j.cpcardiol.2023.102102
M3 - Review article
C2 - 37741596
AN - SCOPUS:85178071089
SN - 0146-2806
VL - 49
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 1
M1 - 102102
ER -