Cancer stem cells: The other face of janus

Sahil Mittal, Randy Mifflin, Don W. Powell

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Advances in the field of stem cell biology have provided renewed hopes that stem cells can be used to treat a wide range of genetic diseases and traumatic injuries. However, advances in the field of cancer cell biology have led to formulation of the cancer stem cell hypothesis, which posits that cancers arise from mutant stem cells. Further, this hypothesis proposes that these stem cells account for cancer recurrence, metastasis, and resistance to conventional treatments. Thus, although normal stem cells represent potential effective solutions to numerous clinical problems, when mutated, they may also represent the cause of many human malignancies.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalAmerican Journal of the Medical Sciences
Issue number2
StatePublished - Aug 2009
Externally publishedYes


  • Cancer stem cells
  • Colorectal cancer
  • Gastrointestinal stem cells

ASJC Scopus subject areas

  • General Medicine


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