California group arboviruses. Electron microscopic studies

Frederick A. Murphy, Sylvia G. Whitfield, Philip H. Coleman, Charles H. Calisher, Erwin R. Rabin, A. Bennett Jenson, Joseph L. Melnick, Mercedes R. Edwards, Elinor Whitney

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.

Original languageEnglish (US)
Pages (from-to)44-56
Number of pages13
JournalExperimental and Molecular Pathology
Issue number1
StatePublished - Aug 1968
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry


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